Anti-PDGFRB Antibody

Raised in rabbit as a polyclonal reagent, this unconjugated primary antibody targets platelet-derived growth factor receptor beta (PDGFRB), a transmembrane tyrosine kinase that drives mesenchymal cell proliferation, pericyte recruitment to vasculature, and fibroblast activation during tissue repair. Researchers studying tumor stroma interactions, fibrotic disease, or vascular biology detect endogenous PDGFRB expression on human samples through western blot, immunohistochemistry on formalin-fixed sections, and immunofluorescence staining.

The reagent is supplied as 100 µl of liquid in a vial, sufficient for multiple staining experiments depending on dilution. Aliquot upon arrival and store at -20°C to preserve activity across freeze-thaw cycles; avoid prolonged exposure to room temperature. The host species is rabbit, clonality is polyclonal, and the conjugate is unconjugated, allowing direct pairing with secondary detection reagents of the researcher's choice, including HRP conjugates, fluorophores, or biotin-streptavidin systems.

Antibodies.com validates reactivity against human PDGFRB. Because PDGFRB is also the molecular target of imatinib and other tyrosine kinase inhibitors, the antibody is frequently used as a research reagent alongside pharmacological studies of receptor signaling in chronic myeloid leukemia, dermatofibrosarcoma protuberans, and hypereosinophilic syndrome research. The reagent is for research use only and is not intended for diagnostic or therapeutic applications.