Anti-PDGFR-β Antibody

Raised in rabbit against platelet-derived growth factor receptor beta, this unconjugated polyclonal antibody from Antibodies.com is supplied at 100 µl for WB, IHC, IF, and ELISA workflows. It is reactive with Human, Mouse, and Rat samples, fitting translational research programs that compare patient-derived material with rodent disease models.

PDGFR-β is a receptor tyrosine kinase central to mesenchymal cell behavior, including fibroblast activation, pericyte recruitment, vascular smooth muscle cell proliferation, and tumor stromal remodeling. Researchers studying glioblastoma use anti-PDGFR-β reagents to interrogate amplified receptor signaling, while fibrosis projects in lung, kidney, and liver rely on the same target to mark activated fibroblasts and myofibroblasts. The antibody also supports wound healing studies, where PDGFR-β marks mesenchymal progenitors during tissue repair, and developmental biology work where it traces pericyte-vessel interactions in the mouse embryo.

For western blot, the polyclonal format increases the likelihood of detecting the full-length receptor and any truncated or proteolytic fragments that arise in disease contexts. In immunohistochemistry and immunofluorescence on formalin-fixed or frozen sections, it labels stromal fibroblasts, perivascular cells, and mesenchymal tumor compartments, helping distinguish reactive stroma from neoplastic epithelium. For ELISA-based quantitation, the unconjugated antibody can be paired with user-supplied detection reagents.

Aliquot upon first use to limit freeze-thaw cycles, store at -20°C in working aliquots, and protect from light. Brief centrifugation before opening the vial will recover any antibody that has collected at the cap or sides during shipping.