Anti-PDE4D Antibody

Raised in rabbit, this unconjugated polyclonal antibody recognizes phosphodiesterase 4D (PDE4D), a cAMP-hydrolyzing enzyme that regulates intracellular cyclic AMP signaling across many tissues. Validated for western blot and immunohistochemistry workflows on human, mouse, and rat samples, the reagent ships as 100 µl of liquid antiserum; refrigerate for short-term use or freeze in working aliquots to limit freeze-thaw loss of titer. PDE4D belongs to the type 4 phosphodiesterase family whose members hydrolyze cyclic AMP and shape the duration of cAMP-dependent responses downstream of β-adrenergic receptors and other G-protein-coupled receptors. Selective PDE4 inhibitors modulate cAMP pools in immune cells, airway smooth muscle, and central nervous system neurons, which keeps this isoform a focus of inflammatory, respiratory, and neurological disease research. Investigators mapping cAMP turnover in cell culture and tissue sections, profiling PDE4 isoform expression across rodent and human specimens, or characterizing PDE4D involvement in cognition, mood regulation, and airway inflammation can use this reagent as an unconjugated primary antibody compatible with HRP- or fluorophore-conjugated secondary detection. Each lot from Antibodies.com is documented with host, clonality, conjugate status, and species reactivity to support reproducible immunoblotting and staining experiments.