Anti-PDE4A Antibody

This primary antibody from Antibodies.com targets phosphodiesterase 4A (PDE4A), a cAMP-specific hydrolase belonging to the PDE4 enzyme family. The reagent is a rabbit polyclonal IgG preparation supplied as 100 µl of unconjugated antisera, intended for detection of endogenous PDE4A in human samples.

Validated applications include Western blot for protein-level expression analysis and immunohistochemistry for localization in fixed tissue sections. The unconjugated format allows flexibility in choosing reporter-conjugated secondary antibodies and detection chemistries, supporting chromogenic or fluorescence-based imaging workflows depending on the experimental design.

PDE4A participates in intracellular cAMP signaling and is broadly expressed across tissues including brain, immune cells, and airway epithelium. Researchers investigating cAMP pathway regulation, inflammatory signaling, neurobiology, or pulmonary pharmacology use this reagent to probe PDE4A abundance and distribution in cell lysates and tissue specimens.

The polyclonal format offers recognition of multiple epitopes across the target protein, which can be advantageous when working with samples where a monoclonal reagent may fail to bind due to polymorphism, post-translational modification, or partial degradation. Storage and handling guidance provided with the vial should be followed to preserve antibody activity across multiple experiments.