Anti-PDE1C Antibody

Raised in rabbit hosts and affinity-purified as a polyclonal IgG preparation, this unconjugated reagent from Antibodies.com is calibrated for detection of phosphodiesterase 1C (PDE1C), the calcium/calmodulin-dependent dual-substrate enzyme encoded at chromosomal locus 7p14.3 (Entrez Gene ID 5137, UniProt Q14123). The reagent is supplied in a 100 µl volume and validated for Western blot across human, mouse, and rat samples.

PDE1C is one of three calmodulin-activated phosphodiesterases (PDE1A, PDE1B, PDE1C) and hydrolyzes both cyclic AMP and cyclic GMP, generating the corresponding nucleoside 5'-monophosphates. The enzyme regulates vascular smooth muscle proliferation and migration, contributes to pathological neointimal hyperplasia, and influences the stability of growth factor receptors such as PDGF-receptor-beta. Biased expression is seen in human heart (RPKM 9.1) and brain (RPKM 4.0), reflecting its established roles in cardiac calcium handling and central nervous system signal transduction. Known aliases include Hcam3, hCam-3, cam-PDE 1C, and DFNA74.

For Western blot workflows, the reagent pairs with standard HRP-conjugated anti-rabbit secondary antibodies and chemiluminescent detection; aliquoting upon first use is recommended to limit repeated freeze-thaw cycles, and the vial should be stored at -20 °C for long-term stability. Catalogue reference A14504 ships at a 100 µl pack size with lot-specific data including recommended blocking conditions, primary incubation times, and working dilutions tailored to your sample type. For research use only.