Anti-PDE1B Antibody

PDE1B is a calcium/calmodulin-dependent phosphodiesterase that hydrolyzes the second messengers cAMP and cGMP, with enriched expression in striatal medium spiny neurons where it shapes dopaminergic and glutamatergic signaling linked to motor control, reward processing, and memory. The Antibodies.com rabbit polyclonal reagent targets this enzyme and supports detection in human, mouse, and rat samples across Western blot, immunohistochemistry, and immunofluorescence workflows. Supplied unconjugated in a 100 µL vial, the antibody allows researchers to pair it with a chosen secondary label and apply it to studies of striatal phosphodiesterase activity, neuropsychiatric disease models, and cyclic nucleotide regulation in neural tissue. The polyclonal format recognizes multiple epitopes on PDE1B, which can improve tolerance to minor sample variation and aid visualization of enzyme distribution across brain regions and peripheral tissues.