Anti-PDE1B Antibody

This polyclonal antibody from Antibodies.com targets PDE1B (Phosphodiesterase 1B), a calcium/calmodulin-dependent enzyme that hydrolyzes the cyclic nucleotides cAMP and cGMP. PDE1B is highly expressed in striatal medium spiny neurons, where it modulates dopaminergic and glutamatergic signaling cascades implicated in motor control, learning, and memory. The reagent is supplied as a 100 µl liquid aliquot at 1 mg/ml in PBS with 0.1% Sodium Azide and 50% glycerol, allowing direct use in Western blot, immunohistochemistry, and immunofluorescence workflows.

Raised in rabbit, the unconjugated antibody detects the human PDE1B protein and shows reactivity toward mouse and rat orthologs, supporting cross-species comparative studies. The 50% glycerol formulation permits storage at -20°C with minimal freeze-thaw cycling, and aliquoting upon first use helps preserve activity. Investigators characterizing basal ganglia circuits, dopaminergic signaling, or PDE1B inhibitor pharmacology can apply this reagent to expression profiling and subcellular localization studies in neural and peripheral tissues.