Anti-PCM1 Antibody

This rabbit polyclonal antibody targets PCM1 (Pericentriolar Material 1), a centrosomal scaffold protein implicated in centriolar satellite dynamics, mitotic spindle organization, and primary cilia formation. Raised in rabbit and purified to IgG isotype, the unconjugated reagent is supplied by Antibodies.com as a 200 µl volume suited to multiple experimental runs.

The antibody shows reactivity against both human and mouse PCM1, supporting cross-species studies in cell and developmental biology models. Validated applications include Western blot (WB) for detecting PCM1 expression across whole-cell lysates and immunohistochemistry (IHC) for visualizing pericentriolar localization in fixed tissue sections. These formats make the reagent a practical tool for researchers exploring centrosome-associated signaling, ciliopathy mechanisms, and PCM1-linked pathways in oncology and neuroscience.

Because PCM1 is a structural component of centriolar satellites, accurate detection in immunostaining depends on fixation protocols that preserve pericentriolar architecture. Investigators commonly pair this antibody with cytoskeletal or centrosomal markers to study microtubule nucleation, mitotic fidelity, and satellite-derived cargo trafficking. Standard IgG storage applies, and aliquoting upon arrival is recommended to limit repeated freeze-thaw cycles and preserve lot-to-lot performance.