Anti-PCM1 Antibody

This polyclonal antibody from Antibodies.com targets Pericentriolar Material 1 (PCM1), a centrosomal scaffold protein required for centriole duplication, microtubule organization, and primary cilium formation. Raised in rabbit and purified as an IgG preparation, the unconjugated reagent is supplied as a 100 µl vial and is validated for western blot and immunohistochemistry workflows on human and mouse samples.

PCM1 localizes to centriolar satellites and participates in cell cycle progression, neuronal migration, and the DNA damage response. Genetic studies link PCM1 disruption to schizophrenia-spectrum disorders, and chromosomal rearrangements involving the PCM1 locus generate oncogenic kinase fusions such as the RET/PCM1 chimera observed in papillary thyroid carcinoma. Researchers investigating centrosome biology, ciliogenesis, or mitotic fidelity commonly employ anti-PCM1 antibodies to visualize pericentriolar satellites by immunofluorescence or to assess protein levels across disease and control tissue lysates by WB.