Anti-PCCB Antibody

PCCB encodes the beta subunit of propionyl-CoA carboxylase, a biotin-dependent mitochondrial enzyme that converts propionyl-CoA to methylmalonyl-CoA during catabolism of valine, isoleucine, methionine, threonine, and odd-chain fatty acids. This unconjugated rabbit polyclonal reagent from Antibodies.com is raised against human PCCB and cross-reacts with the corresponding mouse and rat orthologs, supporting translational studies across common model systems.

Provided as 100 µl in a single vial, the antibody is validated for Western blot, immunohistochemistry on fixed tissue sections, and immunofluorescence imaging. For best results, aliquot upon receipt and store at -20°C, avoiding repeated freeze-thaw cycles to preserve binding activity. Investigators focused on inborn errors of metabolism such as propionic acidemia, mitochondrial biogenesis, and hepatocyte or fibroblast biology can use this reagent to confirm PCCB expression at the protein level and to probe the integrity of the propionate pathway in patient-derived samples and engineered cell lines.