Anti-Patched Antibody

The Patched receptor (PTCH1) is a central regulator of the Hedgehog signaling pathway, where it acts as the ligand-binding receptor for Sonic Hedgehog and related morphogens. This rabbit polyclonal reagent from Antibodies.com is raised against the Patched protein and is validated for Western blot and immunohistochemistry workflows on human and mouse samples. Because it is polyclonal, it recognizes multiple epitopes of the target, and the unconjugated format allows flexible pairing with a wide selection of secondary antibodies and detection chemistries. The 100 µl volume provides ample material for multiple blotting membranes or tissue-staining experiments.

Patched is widely studied in developmental biology, stem cell research, and cancer biology. Loss-of-function mutations in PTCH1 are linked to Gorlin syndrome (nevoid basal cell carcinoma syndrome), sporadic basal cell carcinoma, and medulloblastoma, while pathway activation is implicated in rhabdomyosarcoma and other Hedgehog-driven tumors. Researchers investigating neural tube patterning, limb and skin morphogenesis, cerebellar granule cell proliferation, or pathway dysregulation in tumor models use this reagent to map receptor localization in tissue sections and to compare wild-type versus mutant expression levels in cell lysates.