Anti-PANX1 Antibody

Raised in rabbit against human pannexin 1 (PANX1), this unconjugated polyclonal primary antibody from Antibodies.com recognizes a large-conductance membrane channel central to ATP release, purinergic signaling through the PANX1-P2X7 complex, and inflammasome activation.

Shipped as 100 µL of unconjugated antiserum, the reagent is validated for Western blot and immunofluorescence workflows on human samples. Investigators use it to track PANX1 expression in erythrocyte, neuronal, and apoptotic cell lysates, including detection of the caspase-cleaved C-terminal fragment that marks channel opening during programmed cell death.

Reported research applications span ischemic injury and neuroinflammation studies that follow PANX1 redistribution at the plasma membrane, atherosclerosis and skin wound healing models that profile channel abundance in vascular and dermal tissue, and epilepsy and taste transduction research examining nucleotide release pathways. The unconjugated format allows pairing with HRP- or fluorophore-conjugated secondary antibodies for chemiluminescent immunoblot development or high-resolution fluorescence imaging workflows.