Anti-PAN3 Antibody

Rabbit polyclonal antibody raised against human PAN3, a component of the PAN2-PAN3 deadenylase complex responsible for cytoplasmic shortening of mRNA poly(A) tails. This unconjugated primary antibody from Antibodies.com is supplied as 100 µl and is validated for Western blot and immunofluorescence workflows on human samples.

PAN3 functions as a scaffold that recognizes poly(A) RNA through its zinc finger domain and recruits the catalytic subunit PAN2 to initiate deadenylation. The protein also interfaces with GW182/TNRC6 family members, linking deadenylation to microRNA-mediated translational repression. Researchers studying mRNA turnover, post-transcriptional gene regulation, and miRNA pathway biology detect endogenous PAN3 in lysates of cultured human cell lines by Western blot and visualize its subcellular distribution by immunofluorescence.

Provided as a liquid polyclonal antiserum fraction in a vial, the reagent is host Rabbit, clonality Polyclonal, conjugate Unconjugated, and reactivity Human, allowing flexible secondary antibody pairing and downstream detection chemistries.