Anti-PAK3 (phospho-S154) Antibody

Phosphorylation at serine 154 is a key regulatory event on p21-activated kinase 3 (PAK3), a brain-enriched serine/threonine kinase from the PAK family that governs cytoskeletal dynamics, dendritic spine morphogenesis, and synaptic plasticity. This rabbit polyclonal antibody from Antibodies.com selectively recognizes the phospho-S154 epitope on PAK3, enabling researchers to track activation-state-dependent signaling in neuronal lysates and brain tissue homogenates. Validated for Western blot (WB), the reagent reacts with human, mouse, and rat PAK3 and is supplied as a 100 µl aliquot at 1 mg/ml in phosphate buffered saline containing 15 mM sodium azide at approximately pH 7.2. The unconjugated format allows flexible pairing with HRP, fluorescent, or biotinylated secondary reagents depending on the detection platform. Common research applications include studies of neurodevelopmental signaling, investigations into X-linked intellectual disability-associated PAK3 variants, and characterization of kinase pathway activity downstream of Rho family GTPases such as Cdc42 and Rac1.