Anti-PAK3 Antibody

An affinity-purified polyclonal reagent from Antibodies.com targeting PAK3, a serine/threonine kinase in the p21-activated kinase family that regulates cytoskeletal dynamics, neuronal signaling, and cell cycle progression.

This unconjugated rabbit antibody is supplied at 100 µl and has been validated for western blot (WB) and immunohistochemistry (IHC) workflows on human and mouse samples. PAK3 expression is particularly relevant in neuroscience research, where the kinase is studied in the context of synaptic plasticity, dendritic spine morphology, and X-linked intellectual disability, since mutations in the PAK3 gene on the X chromosome have been linked to non-syndromic mental retardation.

The polyclonal format allows recognition of multiple epitopes on the target protein, supporting consistent detection across denaturing gel electrophoresis and fixed tissue sections. Researchers commonly apply the antibody at optimized dilutions to investigate PAK3 activation and phosphorylation status in neuronal cell models, brain tissue, and transfected cell lines expressing tagged kinase constructs.