Anti-PAK1 Antibody

Targeting the p21-activated kinase 1 (PAK1) protein, this rabbit polyclonal antibody from Antibodies.com is supplied as 100 µl of unconjugated reagent for use in Western blot (WB) and immunohistochemistry (IHC) workflows. PAK1 is a serine/threonine kinase that regulates cytoskeletal reorganization, cell motility, and downstream signal transduction cascades initiated by Rho family GTPases such as Cdc42 and Rac1. The antibody has been validated against Human, Mouse, and Rat samples, supporting comparative and translational research into PAK1-dependent pathways. Because the reagent is polyclonal, it recognizes multiple epitopes on the target, which can improve signal robustness across experimental conditions and aid detection of splice variants or post-translational modifications. Common applications include investigation of cancer cell invasion and metastasis, neuronal development and synaptic plasticity, and immune cell signaling, where PAK1 contributes to actin dynamics and focal adhesion turnover. The unconjugated format gives researchers flexibility to pair the antibody with compatible secondary reagents and detection chemistries suited to their specific experimental setup.