Anti-PAK1 Antibody

A rabbit polyclonal antibody from Antibodies.com raised against PAK1 (p21-activated kinase 1), a serine/threonine kinase of the STE20 family that operates downstream of the Rac1 and Cdc42 GTPases to drive cytoskeletal reorganization, focal adhesion turnover, and MAPK signaling. Supplied unconjugated at 100 µl per vial, the reagent is validated for western blot, immunohistochemistry, immunofluorescence, and immunoprecipitation, with confirmed reactivity toward human, mouse, and rat samples.

The polyclonal format delivers multi-epitope recognition of the kinase, supporting robust detection in denatured whole-cell lysates as well as in native protein complexes pulled down by immunoprecipitation. PAK1 participates in cell motility, proliferation, and survival pathways, making this reagent a useful tool for cancer invasion studies, neurodevelopment research, and investigations of Rho-family GTPase signaling. Researchers comparing kinase-driven cytoskeletal remodeling across species will benefit from the cross-reactivity profile, and the unconjugated format allows direct conjugation to fluorophores, enzymes, or beads as needed for downstream assays. For short-term handling, store at 4°C; aliquot and freeze at -20°C for longer-term stability to minimize freeze-thaw cycles that can degrade antibody activity.