Anti-PAK1 Antibody

Targeting the serine/threonine kinase PAK1 (p21-activated kinase 1), this rabbit polyclonal IgG reagent from Antibodies.com is supplied unconjugated at 200 µl per vial and validated for Western blot detection of endogenous mouse PAK1. PAK1 serves as a core downstream effector of the small GTPases Cdc42 and Rac1, transducing extracellular signals into cytoskeletal reorganization, focal adhesion turnover, MAPK pathway activation, and proliferation responses. The unconjugated format supports flexible pairing with HRP- or fluorophore-conjugated secondary antibodies, making the reagent adaptable for chemiluminescent and fluorescence imaging workflows. Laboratories studying neuronal differentiation, oncogenic transformation, and Rho-GTPase-coupled signaling cascades in murine cell or tissue lysates use this antibody to monitor the ~68 kDa full-length PAK1 band alongside its activated phospho-Thr423 species. For best stability, store the vial refrigerated, prepare working aliquots, and protect from repeated freeze-thaw cycles to preserve activity across multiple experiments.