Anti-PAD4 Antibody

This rabbit polyclonal antibody from Antibodies.com targets peptidyl arginine deiminase type 4 (PAD4), the nuclear enzyme responsible for converting arginine residues on histones and other substrate proteins to citrulline. PAD4-driven histone citrullination is central to chromatin decondensation during neutrophil extracellular trap formation, and aberrant PAD4 activity is implicated in rheumatoid arthritis, multiple cancers, and inflammatory disease models.

Supplied as 100 µl of unconjugated antiserum raised in rabbit, the reagent is validated for western blot, immunohistochemistry, and immunofluorescence workflows on human samples. Researchers studying NETosis, citrullinated protein biology, or PAD4 inhibitor pharmacology routinely apply this reagent to track endogenous PAD4 expression, confirm CRISPR or siRNA knockdown efficiency, and localize the enzyme in fixed tissue sections and cultured cells.