Anti-p73 (P298) Antibody

Raised in rabbit against a region encompassing residue P298 of the human p73 protein, this polyclonal antibody from Antibodies.com recognizes both full-length and select truncated isoforms of p73, a p53-family transcription factor involved in DNA damage response, developmental regulation, neuronal differentiation, and tumor suppression pathways. The reagent is supplied as 50 µl of purified IgG at 1 mg/ml in phosphate buffered saline (PBS), pH 7.2, containing 0.05% sodium azide as a preservative, and is unconjugated, making it appropriate for use as a primary antibody in downstream detection workflows with secondary reagents chosen by the researcher.

Validated applications include Western blot for detection of endogenous p73 from cultured cell lines and tissue lysates, and immunohistochemistry on formalin-fixed paraffin-embedded sections, with demonstrated reactivity to human, mouse, and rat samples. Because the immunogen corresponds to a conserved central region of p73, the antibody is useful for studies investigating TAp73 and ΔNp73 isoform expression, p73/p53 functional crosstalk, apoptotic signaling, and stress-induced transcriptional responses in cancer biology and neuroscience research.