Anti-p70 S6K (phospho-S411) Antibody

Phosphorylation at serine 411 of p70 S6 kinase (p70 S6K) marks an important regulatory event within the mTOR pathway that controls translation initiation and cell growth. This unconjugated rabbit polyclonal antibody from Antibodies.com selectively detects the phospho-S411 epitope on the 70 kDa kinase, supporting studies of signalling dynamics in human, mouse, and rat samples. Supplied as 100 µl of a 1 mg/ml stock in PBS containing 0.1% sodium azide and 50% glycerol, the reagent works in Western blot analysis of phosphorylated kinase levels and in immunohistochemistry to localize active kinase in tissue sections. Researchers investigating insulin signalling, nutrient sensing, oncogenic transformation, and translational control use this reagent to monitor pathway activation and to distinguish the S411-phosphorylated pool from total p70 S6K protein.