Anti-p70 S6K (F438) Antibody

The p70 S6 kinase (p70 S6K, gene name RPS6KB1) is a serine/threonine kinase that serves as a key downstream effector of the mTORC1 pathway, phosphorylating ribosomal protein S6 to drive protein synthesis, cell growth, and metabolic regulation. This rabbit polyclonal antibody from Antibodies.com was raised against an epitope encompassing the F438 residue within the C-terminal regulatory region of the kinase and is supplied unconjugated for straightforward labeling and multiplexing.

Validated for Western blot and immunohistochemistry on human, mouse, and rat samples, the reagent supports investigation of mTOR-dependent translational control, insulin and amino-acid signaling, and proliferative responses. Researchers commonly pair anti-p70 S6K antibodies with phospho-T389 antibodies to monitor pathway activation, and the polyclonal format provides broad epitope coverage for reliable detection across multiple sample types.

Each vial is supplied at 1 mg/ml in PBS containing 0.1% sodium azide as preservative and 50% glycerol as cryoprotectant, packaged as 100 µl. For handling, aliquot and store at -20 °C, limit freeze-thaw cycles, and protect from light to preserve antibody integrity. Allow the vial to equilibrate to room temperature before opening to minimize condensation and ensure accurate pipetting.