Anti-p70 S6 Kinase (Ab-421) Antibody

This primary antibody from Antibodies.com is a rabbit polyclonal reagent raised against p70 S6 Kinase and directed at an epitope in the C-terminal region of the kinase that includes residue 421. Supplied as an unconjugated IgG preparation at 100 µl per vial, the antibody is validated for western blot and immunohistochemistry on human, mouse, and rat samples.

Investigators working on mTOR-dependent translational control, ribosome biogenesis, and cell size regulation use this reagent to monitor kinase expression and signaling status in lysates and tissue sections. The reagent should be stored at -20 °C in small aliquots to limit freeze-thaw cycles, with short-term handling at 4 °C to preserve binding activity. The unconjugated format allows flexible pairing with secondary antibodies of the researcher's choice, supporting both chromogenic and fluorescence-based detection strategies.

Intended for research use only, this reagent is used in cancer biology, metabolic disease, and neuroscience research where ribosomal S6 kinase activity serves as a key readout of mTOR pathway engagement.