Anti-p70 S6 Kinase (Ab-389) Antibody

This polyclonal antibody from Antibodies.com targets the threonine 389 region of p70 S6 Kinase (also known as RPS6KB1 or S6K1), a key downstream effector of the mTOR signaling pathway. The Ab-389 designation indicates that the reagent was raised against a peptide spanning this site, which is the principal mTORC1-dependent phospho-residue on the kinase and a widely used readout of mTOR pathway activation in growth factor, nutrient, and stress response studies.

Validated for western blot and immunofluorescence applications, the antibody cross-reacts with human, mouse, and rat samples, supporting translational research across cell line and primary tissue models. Investigators commonly use it to probe S6K1 phosphorylation status in studies of protein synthesis regulation, cell proliferation, autophagy, metabolic disorders, and oncology, where dysregulated mTOR activity is a frequent feature.

Supplied as 100 µL of unconjugated rabbit antiserum suitable for downstream labeling or secondary antibody detection. Aliquot upon receipt and store refrigerated to preserve activity across multiple freeze-thaw cycles. The polyclonal format offers broader epitope coverage around the target phospho-site compared with monoclonal alternatives.