Anti-p63 Antibody

This Antibodies.com primary antibody recognizes p63, a transcription factor belonging to the p53 family that governs epithelial stratification, stem cell renewal, and programmed cell death. The reagent is supplied as 100 µl of unconjugated rabbit polyclonal antisera and is validated for Western blot and immunofluorescence applications across human, mouse, and rat samples.

In research and pathology workflows, p63 serves as a marker of basal and myoepithelial cell populations in prostate, breast, salivary gland, and squamous epithelial tissues. The polyclonal antibody mixture targets conserved epitopes within the DNA-binding domain, enabling detection of multiple p63 isoforms, including TAp63 and ΔNp63 variants expressed at characteristic molecular weights in epithelial lysates. Because the reagent is unconjugated, investigators can pair it with custom secondary antibodies or fluorophore conjugates for multiplex imaging or chromogenic detection.

Aliquoting upon first use and refrigerated storage preserve antibody activity across repeated experiments, and the cross-species reactivity profile supports comparative studies that bridge murine disease models with human tissue analysis.