Anti-p63 Antibody

This rabbit polyclonal antibody targets the p63 transcription factor, a member of the p53 gene family that governs epithelial development, stem cell renewal, and stratification of squamous epithelia. Produced by Antibodies.com as a primary antibody reagent, the unconjugated IgG preparation is supplied as a 100 µl aliquot and is validated for Western blotting, immunohistochemistry, and immunofluorescence workflows on human tissue samples.

In routine diagnostic and research settings, anti-p63 staining is widely used as a basal cell marker in prostate biopsies to confirm the presence of an intact basal layer in benign glands, and as a squamous differentiation marker in lung and head-and-neck pathology, where it helps separate squamous cell carcinoma from adenocarcinoma. Researchers studying mammary myoepithelium, skin, cervix, and other stratified epithelia also rely on p63 to identify reserve and progenitor cell populations.

The reagent is supplied as a polyclonal antiserum raised in rabbit. Storage temperature of 4°C is recommended, with aliquoting advised to limit freeze-thaw cycles. Working dilutions vary by application and detection system, and users should consult established IHC and immunofluorescence protocols for guidance on antigen retrieval and blocking conditions.