Anti-p57 (D38) Antibody

A rabbit polyclonal antibody raised against the cyclin-dependent kinase inhibitor p57 (also called p57KIP2, encoded by CDKN1C). The reagent is supplied by Antibodies.com at 1 mg/ml in phosphate buffered saline (PBS) with 0.05% sodium azide, at approximately pH 7.2, and ships as a 50 µl vial.

The p57 target regulates the G1/S transition of the cell cycle and is paternally imprinted in most human tissues. This imprinting pattern is what makes the D38 clone a widely used marker in placental pathology: villous cytotrophoblast and villous stromal cells normally show nuclear p57 expression, while the same lineages in a complete hydatidiform mole show loss of staining because the maternal allele is silenced. Antibodies.com distributes this polyclonal reagent for research use only, supporting studies on cell cycle regulation, trophoblast biology, and molar pregnancy diagnostics.

Validated applications include western blot (WB) and immunohistochemistry (IHC) on human samples. Store refrigerated; protect from light. The unconjugated format allows flexibility in secondary antibody choice for downstream detection workflows.