Anti-p57/CDKN1C Antibody

Raised in rabbit against the cyclin-dependent kinase inhibitor CDKN1C, this polyclonal reagent from Antibodies.com targets p57, a paternally imprinted member of the CIP/KIP family that restrains G1/S cell cycle progression by binding and inhibiting cyclin-CDK complexes. Supplied unconjugated at 1 mg/ml in phosphate buffered saline (PBS) with 0.05% sodium azide at approximately pH 7.2, the antibody ships as a 100 µl aliquot validated for western blot (WB) and immunohistochemistry (IHC) on human tissue. In diagnostic placental pathology, p57 immunostaining is a routine adjunct for distinguishing hydatidiform moles from non-molar gestations: normal villous cytotrophoblast and villous stromal cells show nuclear positivity, whereas complete moles lacking a maternal genome characteristically display absent or markedly reduced staining. Researchers can pair the unconjugated preparation with HRP, biotin, or fluorescent secondary detection systems, and the polyclonal response broadens epitope coverage for both full-length p57 and shorter isoforms generated by alternative translation.