Anti-p53R2 Antibody

The p53R2 protein, also known as RRM2B, is a p53-inducible ribonucleotide reductase subunit that supplies deoxyribonucleotide triphosphates for DNA synthesis and repair following genotoxic stress. Antibodies.com offers a rabbit polyclonal Anti-p53R2 Antibody supplied as 100 µl of unconjugated antiserum, validated for Western blot and ELISA workflows against human, mouse, and rat samples.

The reagent is affinity-purified and tested for reactivity across all three listed species, supporting detection of endogenous p53R2 in cell lysates and tissue homogenates. It recognizes epitopes on the native protein, which localizes to both cytoplasm and nucleus and is upregulated by p53 in response to DNA damage, where it contributes to mitochondrial DNA maintenance and the G1/S cell-cycle checkpoint response.

For Western blot, the antibody can be applied to nitrocellulose or PVDF membranes following standard SDS-PAGE separation; for ELISA applications, it can be used as either capture or detection antibody depending on plate configuration. Store the vial at -20 °C in small aliquots to limit freeze-thaw cycles and protect from light. For research use only.