Anti-p53 (phospho Ser46) Antibody [#36]

The antibody targets the phosphorylated Ser46 residue on p53, a critical tumor suppressor modification linked to DNA damage-induced apoptosis. Phosphorylation at Ser46 is mediated by kinases such as HIPK2 and DYRK2 following severe genotoxic stress, and detecting this modification is widely used to study apoptotic signaling pathways in cancer biology research.

The mouse IgG1 monoclonal clone #36 is supplied as a 100 ug liquid formulation and validated for Western blot, immunohistochemistry, and ELISA applications on human samples. Store aliquots at -20 degrees C or below and avoid repeated freeze-thaw cycles to preserve binding activity. This reagent from Antibodies.com enables researchers to distinguish pro-apoptotic p53 signaling from general p53 activation in cell-based and tissue-based assays.