Anti-p53 (L330) Antibody

For researchers investigating the p53 tumor suppressor pathway, this rabbit polyclonal antibody from Antibodies.com targets p53 (also known as TP53), the most frequently mutated gene in human cancers. Supplied at 1 mg/ml in phosphate buffered saline (PBS) with 0.05% sodium azide at approximately pH 7.2, this unconjugated primary antibody is packaged in a 50 µl vial. The reagent is validated for western blot (WB), immunohistochemistry (IHC), and immunofluorescence (IF) workflows and cross-reacts with p53 from human, mouse, and rat samples, supporting comparative oncology studies, cell signaling investigations, and tissue-based analyses of DNA damage response and apoptosis regulation. Researchers commonly use this antibody to evaluate p53 protein accumulation, mutational effects on stability, and downstream transcriptional targets in cancer cell lines and primary tissue specimens. The unconjugated format provides flexibility for chromogenic detection, custom fluorophore conjugation, or multiplex imaging experiments across multiple model systems.