Anti-P53 (D43) Antibody

This polyclonal reagent from Antibodies.com targets the p53 tumor suppressor protein for immunohistochemistry workflows on human tissue specimens. Raised in rabbit, the antibody is supplied unconjugated at 1 mg/ml in phosphate buffered saline (PBS) containing 0.05% sodium azide at approximately pH 7.2. The 100 µl pack size supports multiple staining runs on formalin-fixed, paraffin-embedded sections, where aberrant nuclear accumulation of p53 is commonly assessed as a marker of TP53 mutation status in cancer research. Polyclonal reactivity against multiple epitopes of the human p53 sequence broadens recognition of both wild-type and mutant conformers frequently encountered in tumor biopsies. The unconjugated format allows pairing with anti-rabbit secondary detection systems suited to chromogenic or fluorescence microscopy. Sodium azide serves as a preservative for refrigerated storage, and aliquoting upon first use helps preserve long-term reagent stability. This reagent is intended for research use only and has not been validated for clinical diagnostic applications.