Anti-p53 Antibody

The polyclonal rabbit antibody from Antibodies.com targets the human p53 tumor suppressor protein, supporting research into genomic stability and oncogenesis. p53, encoded by the TP53 gene, orchestrates cellular responses to DNA damage by triggering cell cycle arrest, programmed cell death (apoptosis), or senescence, making it a central focus in cancer biology, tumor biology, and biomarker discovery. This unconjugated reagent is supplied as 100 µl of polyclonal antiserum raised in rabbit and is validated for Western blot (WB) and ELISA workflows on human samples. Researchers commonly apply it to investigate mutation-driven loss of p53 function, map downstream signaling cascades, or profile tumor biopsies for altered p53 expression patterns. Storage at -20 °C in small aliquots helps preserve antibody activity across multiple freeze-thaw cycles, and the reagent is intended for research use only. The polyclonal format offers recognition of multiple epitopes on the target, which can be advantageous when studying post-translationally modified or mutant forms of the protein in diverse experimental contexts.