Anti-p53 Antibody

The p53 tumor suppressor protein, often termed the "guardian of the genome," is one of the most studied targets in oncology and cell biology research. This rabbit polyclonal antibody from Antibodies.com recognizes p53 and is supplied for Western blot and ELISA workflows. Raised in rabbit and provided as an unconjugated reagent in a 100 µl volume, it supports detection of endogenous p53 in samples of human, mouse, and rat origin, enabling translational studies that bridge rodent model systems and human cancer specimens.

As a primary antibody, it can be paired with a labelled secondary reagent for chemiluminescent Western blot readouts, and adapted into ELISA plates for quantitative p53 measurements in cell lysates. Researchers commonly apply p53 antibodies to investigate DNA damage response pathways, apoptotic signaling, senescence programs, and the mutational status of TP53 in tumor-derived cell lines.

The polyclonal format offers recognition of multiple epitopes on the p53 protein, which is helpful when probing both wild-type and mutant variants expressed in transformed cells.