Anti-p53 Antibody

Generated in Mouse and validated for reactivity against Human p53, this unconjugated monoclonal reagent from Antibodies.com is supplied as 100 µl of purified antibody in a TBS buffer (pH 7.4) containing 1% BSA, 40% glycerol, and 0.05% sodium azide as preservative. The clone is of the IgG2b isotype and is validated for use in western blot, immunocytochemistry, immunohistochemistry, and flow cytometry workflows.

p53 (encoded by TP53) is a 53 kDa transcription factor widely studied as the "guardian of the genome" because it coordinates cellular responses to DNA damage, oncogenic stress, and hypoxia. Loss of p53 function through mutation or deletion is the most common alteration in human cancer, occurring in roughly half of all solid tumors, which makes reliable detection antibodies central to oncology research, biomarker validation, and apoptosis studies. Because this reagent is unconjugated, researchers can pair it with their preferred secondary detection system, and the human-reactive clone is tested on relevant cell lines and tissue samples for both cell-based and tissue-based assays.