Anti-p53 (Acetyl-K370) Antibody

This recombinant monoclonal reagent from Antibodies.com specifically recognizes p53 acetylated at lysine 370, a post-translational mark associated with p53 stabilization and transcriptional activation in the DNA damage response. The unconjugated antibody is supplied as a 100 µl liquid formulation in 1xTBS (pH 7.4) with 1% BSA, 40% glycerol, and 0.05% sodium azide as preservative, ready for direct detection with a secondary reagent of the researcher's choice or for custom conjugation. It has been validated for Western blot and immunocytochemistry/immunofluorescence workflows, and it cross-reacts with p53 derived from human, mouse, and rat samples, supporting studies that compare stress responses across species or that work with rodent disease models. Investigators studying genotoxic signaling, apoptosis, senescence, or chromatin-associated p53 functions will find this reagent useful for monitoring the activated, chromatin-bound pool of p53 rather than total p53 levels. Short-term storage at 4 °C is appropriate for working aliquots, while long-term storage at -20 °C with limited freeze-thaw cycles preserves antibody activity over time.