Anti-P300 / CBP Antibody

P300 and CBP (CREB-binding protein) are paralogous histone acetyltransferases that function as transcriptional coactivators. They remodel chromatin through lysine acetylation of histone and non-histone substrates, and integrate signaling from dozens of transcription factors involved in cell cycle control, differentiation, DNA damage response, and apoptosis. Mutations and translocations affecting EP300 and CREBBP are linked to Rubinstein-Taybi syndrome, diffuse large B-cell lymphoma, and several solid tumors, which keeps these enzymes in active study across oncology, neurodevelopment, and chromatin biology labs.

This unconjugated rabbit polyclonal antibody is raised against an epitope within P300 and shows cross-recognition of CBP, enabling detection of both paralogs. Validated applications include Western blot (WB) on cell and tissue lysates and immunohistochemistry (IHC) on fixed sections. The reagent is supplied as a 100 µl liquid aliquot, with reactivity confirmed against human, mouse, and rat samples. Host species is rabbit; clonality is polyclonal, supporting detection of multiple epitopes on the target.

Researchers studying transcriptional regulation, histone acetylation dynamics, or acetyltransferase-dependent signaling pathways will find this antibody useful for expression profiling, co-immunoprecipitation target validation, and tissue-level localization studies. The product is provided by Antibodies.com and is intended for research use only.