Anti-p300 Antibody

Produced in rabbit and affinity-purified against the EP300 transcriptional coactivator, this polyclonal antibody from Antibodies.com recognizes the human p300 protein, a large ~300 kDa nuclear histone acetyltransferase that acetylates histones and numerous non-histone substrates to remodel chromatin and regulate gene expression.

The unconjugated reagent is supplied as 100 µl of liquid in a single-use vial format, sufficient for multiple western blot and immunohistochemistry experiments. It is validated for WB and IHC applications on human samples and is used in research on transcriptional regulation, cell cycle progression, differentiation, and the DNA damage response, where p300 acts as a scaffold for transcription factors such as p53, HIF-1α, and NF-κB.

Loss-of-function mutations in the EP300 gene are associated with Rubinstein-Taybi syndrome, and altered p300 activity is widely studied in cancer biology and chromatin research. For optimal reagent stability, store refrigerated and protect from light, and minimize freeze-thaw cycles to preserve polyclonal reactivity over time.