Anti-P2RY8 Antibody

The P2RY8 receptor is a G protein-coupled receptor encoded on the X chromosome that has been the focus of lymphoma epigenetics research, where its recurrent promoter methylation and transcriptional silencing are characteristic findings in germinal center-derived B-cell lymphomas, notably Burkitt lymphoma and a subset of diffuse large B-cell lymphomas. This rabbit polyclonal antibody reagent from Antibodies.com is raised against the human P2RY8 target and supplied unconjugated, leaving the choice of secondary label and detection chemistry to the end user.

Shipped as 100 µl of liquid polyclonal antiserum, the antibody is validated for western blot detection of endogenous P2RY8 protein, immunofluorescence staining of fixed cells and tissue sections, and ELISA-based quantification assays. Its polyclonal profile is advantageous when working with low-abundance receptor targets, because multiple epitopes across the P2RY8 protein are recognized simultaneously, improving signal recovery in human lymphoid tissue, primary B-cell preparations, and engineered B-cell line models in which P2RY8 has been experimentally reactivated. Host species is rabbit, clonality is polyclonal, and reported reactivity is human.

For handling, the antibody should be stored refrigerated at 4 °C for routine short-term use; for projects that extend over weeks, aliquoting into smaller volumes and freezing at -20 °C protects polyclonal activity across repeated freeze-thaw cycles, with working aliquots kept on ice during immunostaining sessions.