Anti-p27 Antibody

This polyclonal rabbit antibody from Antibodies.com specifically recognizes p27, a cyclin-dependent kinase inhibitor encoded by the CDKN1B gene that governs the G1 to S phase transition of the cell cycle. By binding and inhibiting cyclin-CDK complexes, p27 acts as a key tumor suppressor whose dysregulation is implicated in cancer progression, making it a frequent subject of oncology and cell biology investigations.

Supplied as a 100 µl vial of unconjugated reagent, the antibody is validated for Western blot, immunohistochemistry, and ELISA workflows, and it cross-reacts with human, mouse, and rat samples to support comparative studies across model systems. Researchers apply this reagent to evaluate cell proliferation status, monitor cell cycle arrest, and explore how therapeutic agents influence checkpoint control in breast, prostate, colorectal, and other tumor types where loss of p27 expression correlates with aggressive disease and poor patient prognosis.