Anti-p18 INK Antibody

p18 INK4c (also known as CDKN2C) is a member of the INK4 family of cyclin-dependent kinase inhibitors that bind CDK4 and CDK6 to halt progression through the G1/S cell cycle checkpoint. This rabbit polyclonal antibody from Antibodies.com is raised against p18 INK and is supplied as an unconjugated reagent in a 100 µL volume, supporting western blot and immunohistochemistry workflows on human, mouse, and rat samples. In western blot, the antibody enables detection of endogenous p18 INK4c expression across proliferating tissues, while immunohistochemistry applications allow researchers to localize the protein in fixed sections, including studies of spermatogonia, hematopoietic lineages, and tumor specimens where INK4 family regulation is altered. The polyclonal format offers recognition of multiple epitopes on the target, useful when probing for isoform-level differences or working with samples where a single monoclonal epitope may be compromised by fixation or processing conditions. Investigators studying cell cycle exit, differentiation programs, and tumor suppressor biology rely on p18 INK4c reagents to track how this inhibitor responds to mitogenic signals and to compare its expression profile with related family members such as p16 INK4a and p14/p19 ARF. The unconjugated presentation allows users to pair the antibody with their preferred secondary detection system, including HRP, biotin, or fluorescent labels, depending on whether chromogenic or fluorescence readout is required. For short-term use, keep the vial refrigerated; for longer storage, freeze aliquots at -20 degrees C to preserve antibody activity across multiple freeze-thaw cycles.