Anti-p15 INK Antibody

This rabbit polyclonal antibody from Antibodies.com targets p15 INK4b, a cyclin-dependent kinase inhibitor encoded by the CDKN2B gene that acts as a tumor suppressor by inducing G1 phase cell cycle arrest through inhibition of CDK4 and CDK6. Raised in rabbit and supplied as an unconjugated reagent in 100 µl volume, the antibody is validated for western blot, immunohistochemistry, and immunofluorescence workflows. It cross-reacts with human, mouse, and rat samples, supporting comparative studies across species in cancer biology and cell cycle research. Researchers commonly deploy this reagent to examine p15 INK4b expression in gliomas, leukemias, melanomas, and other malignancies where CDKN2B is frequently deleted or epigenetically silenced, as well as to probe cell cycle regulation in normal tissue development and stem cell differentiation. The polyclonal format offers recognition of multiple epitopes on the target protein, an advantage when working with low-abundance antigens, post-translationally modified samples, or formalin-fixed paraffin-embedded tissue where epitope accessibility may vary between preparations.