Anti-p130 Cas (phospho-Y410) Antibody

Integrin-mediated adhesion signaling converges on phosphorylation of p130 Cas at tyrosine 410, a Src family kinase-driven modification that controls focal adhesion turnover, cell spreading, and downstream Rac1 activation. Antibodies.com supplies this rabbit polyclonal reagent specifically for selective detection of that phospho-Y410 epitope in cell migration, mechanotransduction, and cytoskeletal remodeling studies.

Provided as a 100 µl vial at 1 mg/ml in phosphate buffered saline with 0.05% sodium azide at approximately pH 7.2, the unconjugated antibody is validated for Western blot (WB) and immunohistochemistry (IHC) workflows. Reactivity extends to human, mouse, and rat samples, supporting translational work on cancer invasion, vascular smooth muscle phenotype switching, and integrin pathway analysis across model systems.

For optimal stability, aliquot upon receipt and store at -20°C, avoiding repeated freeze-thaw cycles. The polyclonal format offers recognition of multiple epitopes flanking the pY410 site, which can improve signal robustness when comparing phosphorylation levels across treated and untreated sample preparations.