Anti-OSR2 (F118) Antibody

This rabbit polyclonal antibody from Antibodies.com targets the OSR2 transcription factor, a zinc-finger protein in the odd-skipped family that governs craniofacial patterning, palate fusion, tooth development, and kidney organogenesis. Supplied as 100 µl of unconjugated IgG at 1 mg/ml in PBS containing 0.05% sodium azide (approx. pH 7.2), the reagent is validated for western blot across human, mouse, and rat samples.

OSR2 functions as a transcriptional regulator that interfaces with BMP and FGF signaling cascades during embryogenesis. Investigators studying cleft palate etiology, dental morphogenesis, or renal development use the antibody to monitor endogenous OSR2 protein levels in tissue lysates and to confirm transcriptomic data at the protein level. The polyclonal format presents multiple epitope recognition sites within the F118 region, producing reliable signal on blots prepared from whole-cell extracts of embryonic or adult tissues.

For western blot applications, dilute the stock into blocking buffer and incubate with transferred membranes; because the primary is supplied unconjugated, an HRP- or fluorophore-conjugated secondary antibody is required for detection. Store refrigerated, protect from light, and limit freeze-thaw events to preserve activity throughout the shelf life of the reagent.