Anti-OSM Antibody

Raised in rabbit, this unconjugated polyclonal antibody binds human Oncostatin M (OSM), a gp130-family cytokine implicated in inflammatory signaling, hepatic regeneration, bone remodeling, and tumor microenvironment studies. Antibodies.com supplies the reagent at 1mg/ml in PBS with 0.1% sodium azide and 50% glycerol, packaged in a 100µl vial that supports multiple immunoblots and tissue-staining runs.

Validated applications include Western blot for protein-level detection in cell lysates and immunohistochemistry for localization in formalin-fixed paraffin-embedded tissue. Researchers investigating cytokine-driven pathways in hepatocellular carcinoma, breast cancer stromal interactions, rheumatoid arthritis synovium, or pulmonary fibrosis can use this reagent to probe OSM expression alongside gp130 and related JAK/STAT effectors. The polyclonal format recognizes multiple epitopes on the mature OSM protein, which can improve signal in IHC where antigen masking is a concern.

Storage at -20°C in working aliquots preserves activity; repeated freeze-thaw cycles should be avoided. The 0.1% sodium azide acts as a microbial preservative. The unconjugated format allows flexible pairing with HRP, biotin, or fluorophore-labeled secondary reagents depending on the assay design.