Anti-OSGEP Antibody

This polyclonal reagent targets O-sialoglycoprotein endopeptidase (OSGEP), the catalytic subunit of the KEOPS complex, which installs the universal threonylcarbamoyl-adenosine (t6A) modification on tRNA. Provided by Antibodies.com as an unconjugated rabbit IgG at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, this 100 µl vial is supplied ready-to-use for western blot and immunohistochemistry workflows. Antibody reactivity has been confirmed against human, mouse, and rat OSGEP, supporting cross-species studies of KEOPS-dependent tRNA modification and the protein's reported links to Galloway-Mowat syndrome. The product format is suited to standard immunoblotting of whole-cell lysates and to chromogenic or fluorescent IHC on fixed tissue sections, with the glycerol-containing buffer allowing storage at -20 °C. Researchers investigating OSGEP loss-of-function models, cancer-associated expression changes, or the broader KEOPS pathway will find this polyclonal antibody useful as a detection reagent, and the unconjugated format permits flexible secondary antibody pairing or direct labelling.