Anti-ORC2 Antibody

This rabbit polyclonal IgG antibody targets ORC2 (Origin Recognition Complex subunit 2), a core component of the six-subunit ORC that recognizes origins of replication and triggers pre-replication complex assembly in eukaryotic cells. Antibodies.com supplies this reagent as an unconjugated polyclonal preparation raised in rabbit, validated for Western blot detection of the human protein at its expected molecular weight.

ORC2 participates in licensing replication origins during the G1 phase and supports the recruitment of downstream factors onto chromatin, which is why antibodies against it appear frequently in studies on DNA replication initiation, chromatin biology, cell-cycle progression, and genome stability. In cancer research and replication-stress investigations, ORC2 immunoblotting serves as a marker for pre-RC integrity and origin firing capacity across human cell lines and patient-derived samples.

Each vial contains 100 µL of antibody. For best practice, aliquot on first thaw and store at -20°C, limiting repeated freeze-thaw cycles to preserve activity. The product is intended for research use only and is supplied as an unconjugated reagent suitable for immunoblotting of human cell and tissue lysates prepared under standard denaturing conditions.