Anti-OPTN Antibody

This rabbit polyclonal antibody from Antibodies.com targets optineurin (OPTN), a multifunctional adaptor protein involved in selective autophagy, NF-κB signaling, and vesicle trafficking. Mutations in OPTN have been linked to primary open-angle glaucoma, amyotrophic lateral sclerosis (ALS), and Paget's disease of bone, making the protein a frequent focus of neurodegeneration, ophthalmology, and inflammation research.

Raised in rabbit and supplied unconjugated, the reagent is validated for Western blot and immunohistochemistry. Cross-reactivity has been confirmed against human, mouse, and rat samples, supporting translational work that spans patient tissue, rodent disease models, and cell-based assays.

Each vial contains 100 µl of liquid antibody. For blotting, researchers apply diluted antibody to membranes; for IHC, the reagent is layered onto fixed tissue sections before chromogenic or fluorescent detection. Store refrigerated and protect from light to maintain performance across multiple experiments.