Anti-OPTN Antibody

Optineurin (OPTN) is a multifunctional scaffolding protein central to selective autophagy, NF-κB signaling, and vesicle trafficking, and it is the gene mutated in primary open-angle glaucoma and in a subset of amyotrophic lateral sclerosis cases. The Antibodies.com rabbit polyclonal reagent binds endogenous OPTN and is validated for Western blot and immunohistochemistry on human, mouse, and rat samples. It ships as 100 µl at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, ready to dilute into standard blocking buffer. Store aliquots frozen at -20 °C and limit freeze-thaw cycles to preserve affinity. The polyclonal format broadens recognition across OPTN isoforms and post-translational states, which is helpful when probing paraffin-embedded tissue where phosphorylation or ubiquitin conjugation may mask individual epitopes.