Anti-OPRM1 (phospho S375) Antibody

Generated in rabbit, this polyclonal IgG reagent selectively detects the mu-opioid receptor (OPRM1) when phosphorylated at serine 375, a well-characterized regulatory residue involved in agonist-driven receptor desensitization, internalization, and downstream β-arrestin recruitment. From Antibodies.com, the antibody is supplied as 50 ul of unconjugated polyclonal IgG and is validated for Western blot on human, mouse, and rat samples, supporting studies of GPCR phosphorylation dynamics, opioid receptor trafficking, and arrestin-dependent signaling in both heterologous cell systems and native neural tissue.

Investigators working on opioid tolerance, chronic agonist exposure, and pain-modulation circuits rely on phospho-site-specific reagents such as this to separate the active, modified receptor pool from total OPRM1 in lysate-based assays. Serine 375 phosphorylation is widely used as an early molecular marker of mu-opioid receptor activation, and tracking this modification alongside total receptor levels supports quantitative interpretation of signaling kinetics, receptor turnover, and desensitization dynamics in cultured neurons, brain homogenates, and transfected cell lines.